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Benchmarks / perturbation-response-unseen-cell-line-sampled-cells

Perturbation DE-gene overlap from predicted cells (Replogle CRISPRi, unseen line)

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single-cell/perturbation-response-unseen-cell-line-sampled-cells Task: regression Visibility: PUBLIC
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Overview

The Replogle CRISPRi unseen-cell-line benchmark (100 knockdowns in held-out HepG2, trained on K562, RPE1 and Jurkat) scored the way cell-eval scores perturbation models: the model returns predicted HepG2 cells, a Wilcoxon test against the HepG2 control cells finds their differentially expressed genes, and the top 20 are compared with each knockdown's measured top-20 DE genes.

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Ranked results, with their source, uncertainty and floors, the protocol and a sample of the data are on the Leaderboard tab.